Ontology highlight
ABSTRACT:
SUBMITTER: Leonardi S
PROVIDER: S-EPMC6429932 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Leonardi Sergio S Franzone Anna A Piccolo Raffaele R McFadden Eugene E Vranckx Pascal P Serruys Patrick P Benit Edouard E Liebetrau Christoph C Janssens Luc L Ferrario Maurizio M Zurakowski Aleksander A van Geuns Robert-Jan RJ Dominici Marcello M Huber Kurt K Slagboom Ton T Buszman Paweł P Bolognese Leonardo L Tumscitz Carlo C Bryniarski Krzysztof K Aminian Adel A Vrolix Mathias M Petrov Ivo I Garg Scot S Naber Christoph C Prokopczuk Janusz J Hamm Christian C Steg Gabriel G Heg Dik D Juni Peter P Windecker Stephan S Valgimigli Marco M
BMJ open 20190309 3
<h4>Introduction</h4>The GLOBAL LEADERS is an open-label, pragmatic and superiority randomised controlled trial designed to challenge the current treatment paradigm of dual antiplatelet therapy (DAPT) for 12 months followed by aspirin monotherapy among patients undergoing percutaneous coronary intervention. By design, all study endpoints are investigator reported (IR) and not subject to formal adjudication by an independent Clinical Event Committee (CEC), which may introduce detection, reporting ...[more]