Circulating fibrinogen to pre-albumin ratio is a promising biomarker for diagnosis of colorectal cancer.

ABSTRACT:

Background

Inflammation and nutrition are closely associated with initiation and progression of colorectal cancer (CRC). This study aimed to investigate the diagnostic value of the FAR (FAR = 100*Fibrinogen/Albumin) and FPR (FPR = Fibrinogen/pre-Albumin) in CRC.

Methods

Neutrophil-to-lymphocyte ratio (NLR), FPR, and FAR were calculated in 455 newly diagnosed CRC patients, 455 healthy individuals, and 455 benign controls with colorectal polyp. The diagnostic value of biomarker for CRC was evaluated by receiver operating characteristic curve (ROC). Logistic regression analysis was adopted to assess the risk factors for telling CRC apart from benign disease. Moreover, the combined biomarkers were used for discriminating between CRC and benign disease.

Results

Neutrophil-

SUBMITTER: Sun F 

PROVIDER: S-EPMC6430345 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature