Dataset Information

Conditional moving linear regression: modeling the recruitment process for ALLHAT.

ABSTRACT: Effective recruitment is a prerequisite for successful execution of a clinical trial. ALLHAT, a large hypertension treatment trial (N = 42, 418), provided an opportunity to evaluate adaptive modeling of recruitment processes using conditional moving linear regression. Our statistical modeling of recruitment, comparing Brownian and fractional Brownian motion, indicates that fractional Brownian motion combined with moving linear regression is better than classic Brownian motion in terms of higher conditional probability of achieving a global recruitment goal in four week ahead projections. Further research is needed to evaluate how recruitment modeling can assist clinical trialists in planning and executing clinical trials. Clinical Trial Registration: www.clinicaltrials.gov NCT00000542.

SUBMITTER: Lai D

PROVIDER: S-EPMC6430572 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Conditional moving linear regression: modeling the recruitment process for ALLHAT.

Lai Dejian D Zhang Qiang Q Yamal Jose-Miguel JM Einhorn Paula T PT Davis Barry R BR

Communications in statistics: theory and methods 20170519 18

Effective recruitment is a prerequisite for successful execution of a clinical trial. ALLHAT, a large hypertension treatment trial (N = 42, 418), provided an opportunity to evaluate adaptive modeling of recruitment processes using conditional moving linear regression. Our statistical modeling of recruitment, comparing Brownian and fractional Brownian motion, indicates that fractional Brownian motion combined with moving linear regression is better than classic Brownian motion in terms of higher ...[more]

PMID: 30906106

Similar Datasets

Project description:Electrophysiological research with event-related brain potentials (ERPs) is increasingly moving from simple, strictly orthogonal stimulation paradigms towards more complex, quasi-experimental designs and naturalistic situations that involve fast, multisensory stimulation and complex motor behavior. As a result, electrophysiological responses from subsequent events often overlap with each other. In addition, the recorded neural activity is typically modulated by numerous covariates, which influence the measured responses in a linear or non-linear fashion. Examples of paradigms where systematic temporal overlap variations and low-level confounds between conditions cannot be avoided include combined electroencephalogram (EEG)/eye-tracking experiments during natural vision, fast multisensory stimulation experiments, and mobile brain/body imaging studies. However, even "traditional," highly controlled ERP datasets often contain a hidden mix of overlapping activity (e.g., from stimulus onsets, involuntary microsaccades, or button presses) and it is helpful or even necessary to disentangle these components for a correct interpretation of the results. In this paper, we introduce unfold, a powerful, yet easy-to-use MATLAB toolbox for regression-based EEG analyses that combines existing concepts of massive univariate modeling ("regression-ERPs"), linear deconvolution modeling, and non-linear modeling with the generalized additive model into one coherent and flexible analysis framework. The toolbox is modular, compatible with EEGLAB and can handle even large datasets efficiently. It also includes advanced options for regularization and the use of temporal basis functions (e.g., Fourier sets). We illustrate the advantages of this approach for simulated data as well as data from a standard face recognition experiment. In addition to traditional and non-conventional EEG/ERP designs, unfold can also be applied to other overlapping physiological signals, such as pupillary or electrodermal responses. It is available as open-source software at http://www.unfoldtoolbox.org.

Dataset Information

Conditional moving linear regression: modeling the recruitment process for ALLHAT.

Publications

Conditional moving linear regression: modeling the recruitment process for ALLHAT.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets