Ontology highlight
ABSTRACT:
SUBMITTER: Bertolio R
PROVIDER: S-EPMC6430766 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Nature communications 20190322 1
Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several enzymes required for cholesterol, fatty acid, triacylglycerol and phospholipid synthesis. In vertebrates, SREBP activation is mainly controlled by a complex and well-characterized feedback mechanism mediated by cholesterol, a crucial bio-product of the SREBP-activated mevalonate pathway. In this work, we identified ac ...[more]