Ontology highlight
ABSTRACT:
SUBMITTER: Baron RM
PROVIDER: S-EPMC6431081 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Baron Rebecca M RM Kwon Min-Young MY Castano Ana P AP Ghanta Sailaja S Riascos-Bernal Dario F DF Lopez-Guzman Silvia S Macias Alvaro Andres AA Ith Bonna B Schissel Scott L SL Lederer James A JA Reeves Raymond R Yet Shaw-Fang SF Layne Matthew D MD Liu Xiaoli X Perrella Mark A MA
Journal of leukocyte biology 20180705 4
High mobility group (HMG) proteins are a family of architectural transcription factors, with HMGA1 playing a role in the regulation of genes involved in promoting systemic inflammatory responses. We speculated that blocking HMGA1-mediated pathways might improve outcomes from sepsis. To investigate HMGA1 further, we developed genetically modified mice expressing a dominant negative (dn) form of HMGA1 targeted to the vasculature. In dnHMGA1 transgenic (Tg) mice, endogenous HMGA1 is present, but it ...[more]