A Rat Model of Radiation Vasculitis for the Study of Mesenchymal Stem Cell-Based Therapy.

ABSTRACT: Radiation vasculitis is one of the most common detrimental effects of radiotherapy for malignant tumors. This is developed at the vasculature of adjacent organs. Animal experiments have showed that transplantation of mesenchymal stem cells (MSCs) restores vascular function after irradiation. But the population of MSCs being engrafted into irradiated vessels is too low in the conventional models to make assessment of therapeutic effect difficult. This is presumably because circulating MSCs are dispersed in adjacent tissues being irradiated simultaneously. Based on the assumption, a rat model, namely, RT (radiation) plus TX (transplantation), was established to promote MSC homing by sequestering irradiated vessels. In this model, a 1.5 cm long segment of rat abdominal aorta was irradiated by

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6431386 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature