Ontology highlight
ABSTRACT:
SUBMITTER: Richmond JM
PROVIDER: S-EPMC6431571 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Richmond Jillian M JM Strassner James P JP Rashighi Mehdi M Agarwal Priti P Garg Madhuri M Essien Kingsley I KI Pell Lila S LS Harris John E JE
The Journal of investigative dermatology 20181110 4
Tissue resident memory T cells (Trm) form in the skin in vitiligo and persist to maintain disease, as white spots often recur rapidly after discontinuing therapy. We and others have recently described melanocyte-specific autoreactive Trm in vitiligo lesions. Here, we characterize the functional relationship between Trm and recirculating memory T cells (Tcm) in our vitiligo mouse model. We found that both Trm and Tcm sensed autoantigen in the skin long after stabilization of disease, producing IF ...[more]