Ontology highlight
ABSTRACT:
SUBMITTER: Rocamora-Reverte L
PROVIDER: S-EPMC6431616 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Rocamora-Reverte Lourdes L Tuzlak Selma S von Raffay Laura L Tisch Marcel M Fiegl Heidi H Drach Mathias M Reichardt Holger M HM Villunger Andreas A Tischner Denise D Wiegers G Jan GJ
Frontiers in immunology 20190318
Activation of the immune system increases systemic adrenal-derived glucocorticoid (GC) levels which downregulate the immune response as part of a negative feedback loop. While CD4<sup>+</sup> T cells are essential target cells affected by GC, it is not known whether these hormones exert their major effects on CD4<sup>+</sup> helper T cells, CD4<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells (Treg cells), or both. Here, we generated mice with a specific deletion of the glucocorticoid receptor (G ...[more]