Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6432666 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Zhang Yide Y Nichols Ev L EL Zellmer Abigail M AM Guldner Ian H IH Kankel Cody C Zhang Siyuan S Howard Scott S SS Smith Cody J CJ
Development (Cambridge, England) 20190308 5
Super-resolution microscopy is broadening our in-depth understanding of cellular structure. However, super-resolution approaches are limited, for numerous reasons, from utilization in longer-term intravital imaging. We devised a combinatorial imaging technique that combines deconvolution with stepwise optical saturation microscopy (DeSOS) to circumvent this issue and image cells in their native physiological environment. Other than a traditional confocal or two-photon microscope, this approach r ...[more]