Ontology highlight
ABSTRACT:
SUBMITTER: Williams RC
PROVIDER: S-EPMC6432927 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Williams R C RC Muller Y L YL Hanson R L RL Knowler W C WC Mason C C CC Bian L L Ossowski V V Wiedrich K K Chen Y F YF Marcovina S S Hahnke J J Nelson R G RG Baier L J LJ Bogardus C C
Diabetologia 20110412 7
<h4>Aims/hypothesis</h4>We sought to identify the physiological implications of genetic variation at the HLA-DRB1 region in full-heritage Pima Indians in Arizona.<h4>Methods</h4>Single-nucleotide polymorphisms from the HLA region on chromosome 6p were tested for association with skeletal muscle mRNA expression of HLA-DRB1 and HLA-DRA, and with type 2 diabetes mellitus and prediabetic traits.<h4>Results</h4>The A allele at rs9268852, which tags HLA-DRB1 02(1602), was associated both with higher H ...[more]