Ontology highlight
ABSTRACT:
SUBMITTER: Yamamoto N
PROVIDER: S-EPMC6433047 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Yamamoto Naoka N Kashiwagi Manabu M Ishihara Manami M Kojima Takaaki T Maturana Andrés D AD Kuroda Shun'ichi S Niimi Tomoaki T
The Journal of biological chemistry 20190130 12
The signaling pathways that are mediated by Slit ligands and their Roundabout (Robo) family of receptors play multifunctional roles in the development of the nervous system and other organs. A recent study identified neural epidermal growth factor-like (NEL)-like 2 (NELL2) as a novel ligand for Robo3. In this study, we carried out a comprehensive analysis of the interaction between NELL1 and the Robo family of receptors and demonstrated that Robo2 contains a cryptic binding site for both NELL1 a ...[more]