Ontology highlight
ABSTRACT:
SUBMITTER: Bucki R
PROVIDER: S-EPMC6433049 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Bucki Robert R Wang Yu-Hsiu YH Yang Changsong C Kandy Sreeja Kutti SK Fatunmbi Ololade O Bradley Ryan R Pogoda Katarzyna K Svitkina Tatyana T Radhakrishnan Ravi R Janmey Paul A PA
The Journal of biological chemistry 20190128 12
Spatial and temporal control of actin polymerization is fundamental for many cellular processes, including cell migration, division, vesicle trafficking, and response to agonists. Many actin-regulatory proteins interact with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P<sub>2</sub>) and are either activated or inactivated by local PI(4,5)P<sub>2</sub> concentrations that form transiently at the cytoplasmic face of cell membranes. The molecular mechanisms of these interactions and how the dozen ...[more]