Parallel adaptation of rabbit populations to myxoma virus.
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ABSTRACT:
SUBMITTER: Alves JM
PROVIDER: S-EPMC6433279 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Parallel adaptation of rabbit populations to myxoma virus.
Alves Joel M JM Carneiro Miguel M Cheng Jade Y JY Lemos de Matos Ana A Rahman Masmudur M MM Loog Liisa L Campos Paula F PF Wales Nathan N Eriksson Anders A Manica Andrea A Strive Tanja T Graham Stephen C SC Afonso Sandra S Bell Diana J DJ Belmont Laura L Day Jonathan P JP Fuller Susan J SJ Marchandeau Stéphane S Palmer William J WJ Queney Guillaume G Surridge Alison K AK Vieira Filipe G FG McFadden Grant G Nielsen Rasmus R Gilbert M Thomas P MTP Esteves Pedro J PJ Ferrand Nuno N Jiggins Francis M FM
Science (New York, N.Y.) 20190214 6433
In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in ...[more]
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