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Impact of Age on the Efficacy and Safety of Alirocumab in Patients with Heterozygous Familial Hypercholesterolemia.


ABSTRACT: PURPOSE:This post-hoc analysis examined whether age modified the efficacy and safety of alirocumab, a PCSK9 inhibitor, in patients with heterozygous familial hypercholesterolemia (HeFH), using pooled data from four 78-week placebo-controlled phase 3 trials (ODYSSEY FH I, FH II, LONG TERM, and HIGH FH). METHODS:Data from 1257 patients with HeFH on maximally tolerated statin ± other lipid-lowering therapies were analyzed by an alirocumab dose regimen and by age subgroups (18 to

SUBMITTER: Ginsberg HN 

PROVIDER: S-EPMC6433806 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Impact of Age on the Efficacy and Safety of Alirocumab in Patients with Heterozygous Familial Hypercholesterolemia.

Ginsberg Henry N HN   Tuomilehto Jaakko J   Hovingh G Kees GK   Cariou Bertrand B   Santos Raul D RD   Brown Alan S AS   Sanganalmath Santosh K SK   Koren Andrew A   Thompson Desmond D   Raal Frederick J FJ  

Cardiovascular drugs and therapy 20190201 1


<h4>Purpose</h4>This post-hoc analysis examined whether age modified the efficacy and safety of alirocumab, a PCSK9 inhibitor, in patients with heterozygous familial hypercholesterolemia (HeFH), using pooled data from four 78-week placebo-controlled phase 3 trials (ODYSSEY FH I, FH II, LONG TERM, and HIGH FH).<h4>Methods</h4>Data from 1257 patients with HeFH on maximally tolerated statin ± other lipid-lowering therapies were analyzed by an alirocumab dose regimen and by age subgroups (18 to < 45  ...[more]

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