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Interactions between plasma copper concentrations and SOD1 gene polymorphism for impaired glucose regulation and type 2 diabetes.

ABSTRACT: AIMS:To examine the associations of plasma copper concentrations and superoxide dismutase 1 (SOD1) polymorphisms as well as their gene-environment interaction with newly diagnosed impaired glucose regulation (IGR) and type 2 diabetes (T2D). METHODS:We performed a large case-control study in 2520 Chinese Han subjects: 1004 newly diagnosed T2D patients, 512 newly diagnosed IGR patients and 1004 individuals with normal glucose tolerance. RESULTS:After multivariable adjustment, the ORs (95% CIs) of T2D across tertiles of plasma copper were 1.00 (reference), 1.85 (95% CI: 1.39, 2.45), and 4.21 (95% CI: 3.20, 5.55) (P-trend?

SUBMITTER: Yin J

PROVIDER: S-EPMC6434161 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Interactions between plasma copper concentrations and SOD1 gene polymorphism for impaired glucose regulation and type 2 diabetes.

Yin Jiawei J Wang Xiaoqian X Li Shuzhen S Zhu Yalun Y Chen Sijing S Li Peiyun P Luo Cheng C Huang Yue Y Li Xiaoqin X Hu Xueting X Yang Wei W Bao Wei W Shan Zhilei Z Liu Liegang L

Redox biology 20190318

<h4>Aims</h4>To examine the associations of plasma copper concentrations and superoxide dismutase 1 (SOD1) polymorphisms as well as their gene-environment interaction with newly diagnosed impaired glucose regulation (IGR) and type 2 diabetes (T2D).<h4>Methods</h4>We performed a large case-control study in 2520 Chinese Han subjects: 1004 newly diagnosed T2D patients, 512 newly diagnosed IGR patients and 1004 individuals with normal glucose tolerance.<h4>Results</h4>After multivariable adjustment, ...[more]

PMID: 30909159

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