Selective micro-structural integrity impairment of the isthmus subregion of the corpus callosum in alcohol-dependent males.

ABSTRACT:

Background

Previous studies have provided evidence that alcohol-dependent patients have abnormality in corpus callosum (CC); however, it is unclear whether micro-structural integrity of the CC subregions is differentially affected in this disorder.

Methods

In this study, a total of 39 male individuals, including 19 alcohol-dependent patients and 20 age-matched healthy controls, underwent diffusion tensor imaging (DTI). CC was reconstructed by DTI tractography and was divided into seven subregions. Multiple diffusion metrics of each subregion were compared between two groups.

Results

Compared to healthy controls, patients exhibited increased axial diffusivity (P = 0.007), radial diffusivity (P = 0.009) and mean diffusivity (P = 0.005) in the isthmus. In addition, we ob

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6434796 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature