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When are static and adjustable robust optimization problems with constraint-wise uncertainty equivalent?

ABSTRACT: Adjustable robust optimization (ARO) generally produces better worst-case solutions than static robust optimization (RO). However, ARO is computationally more difficult than RO. In this paper, we provide conditions under which the worst-case objective values of ARO and RO problems are equal. We prove that when the uncertainty is constraint-wise, the problem is convex with respect to the adjustable variables and concave with respect to the uncertain parameters, the adjustable variables lie in a convex and compact set and the uncertainty set is convex and compact, then robust solutions are also optimal for the corresponding ARO problem. Furthermore, we prove that if some of the uncertain parameters are constraint-wise and the rest are not, then under a similar set of assumptions there is an optimal decision rule for the ARO problem that does not depend on the constraint-wise uncertain parameters. Also, we show for a class of problems that using affine decision rules that depend on all of the uncertain parameters yields the same optimal objective value as when the rules depend solely on the non-constraint-wise uncertain parameters. Finally, we illustrate the usefulness of these results by applying them to convex quadratic and conic quadratic problems.

SUBMITTER: Marandi A

PROVIDER: S-EPMC6435025 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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When are static and adjustable robust optimization problems with constraint-wise uncertainty equivalent?

Marandi Ahmadreza A den Hertog Dick D

Mathematical programming 20170612 2

Adjustable robust optimization (ARO) generally produces better worst-case solutions than static robust optimization (RO). However, ARO is computationally more difficult than RO. In this paper, we provide conditions under which the worst-case objective values of ARO and RO problems are equal. We prove that when the uncertainty is constraint-wise, the problem is convex with respect to the adjustable variables and concave with respect to the uncertain parameters, the adjustable variables lie in a c ...[more]

PMID: 30996478

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Project description:BACKGROUND: An important step in strain optimization is to identify reactions whose activities should be modified to achieve the desired cellular objective. Preferably, these reactions are identified systematically, as the number of possible combinations of reaction modifications could be very large. Over the last several years, a number of computational methods have been described for identifying combinations of reaction modifications. However, none of these methods explicitly address uncertainties in implementing the reaction activity modifications. In this work, we model the uncertainties as probability distributions in the flux carrying capacities of reactions. Based on this model, we develop an optimization method that identifies reactions for flux capacity modifications to predict outcomes with high statistical likelihood. RESULTS: We compare three optimization methods that select an intervention set comprising up- or down-regulation of reaction flux capacity: CCOpt (Chance constrained optimization), DetOpt (Deterministic optimization), and MCOpt (Monte Carlo-based optimization). We evaluate the methods using a Monte Carlo simulation-based method, MCEval (Monte Carlo Evaluations). We present two case studies analyzing a CHO cell and an adipocyte model. The flux capacity distributions required for our methods were estimated from maximal reaction velocities or elementary mode analysis. The intervention set selected by CCOpt consistently outperforms the intervention set selected by DetOpt in terms of tolerance to flux capacity variations. MCEval shows that the optimal flux predicted based on the CCOpt intervention set is more likely to be obtained, in a probabilistic sense, than the flux predicted by DetOpt. The intervention sets identified by CCOpt and MCOpt were similar; however, the exhaustive sampling required by MCOpt incurred significantly greater computational cost. CONCLUSIONS: Maximizing tolerance to variable engineering outcomes (in modifying enzyme activities) can identify intervention sets that statistically improve the desired cellular objective.

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When are static and adjustable robust optimization problems with constraint-wise uncertainty equivalent?

Publications

When are static and adjustable robust optimization problems with constraint-wise uncertainty equivalent?

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