Ontology highlight
ABSTRACT:
SUBMITTER: Lieb S
PROVIDER: S-EPMC6435321 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
eLife 20190325
Targeted cancer therapy is based on exploiting selective dependencies of tumor cells. By leveraging recent functional screening data of cancer cell lines we identify Werner syndrome helicase (WRN) as a novel specific vulnerability of microsatellite instability-high (MSI-H) cancer cells. MSI, caused by defective mismatch repair (MMR), occurs frequently in colorectal, endometrial and gastric cancers. We demonstrate that WRN inactivation selectively impairs the viability of MSI-H but not microsatel ...[more]