Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration.
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ABSTRACT:
SUBMITTER: Storti F
PROVIDER: S-EPMC6435327 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration.
Storti Federica F Klee Katrin K Todorova Vyara V Steiner Regula R Othman Alaa A van der Velde-Visser Saskia S Samardzija Marijana M Meneau Isabelle I Barben Maya M Karademir Duygu D Pauzuolyte Valda V Boye Sanford L SL Blaser Frank F Ullmer Christoph C Dunaief Joshua L JL Hornemann Thorsten T Rohrer Lucia L den Hollander Anneke A von Eckardstein Arnold A Fingerle Jürgen J Maugeais Cyrille C Grimm Christian C
eLife 20190313
Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment epithelium (RPE) and the retina leading to loss of central vision. Polymorphisms in genes involved in lipid metabolism, including the ATP-binding cassette transporter A1 (<i>ABCA1</i>), have been associated with AMD risk. However, the significance of retinal lipid handling for AMD pathogenesis remains elusive. Here, we study the contribution of lipid efflux in the RPE by generating a mouse model lacking ABCA1 ...[more]
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