Ontology highlight
ABSTRACT:
SUBMITTER: Meddeb R
PROVIDER: S-EPMC6435718 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Meddeb Romain R Dache Zahra Al Amir ZAA Thezenas Simon S Otandault Amaëlle A Tanos Rita R Pastor Brice B Sanchez Cynthia C Azzi Joelle J Tousch Geoffroy G Azan Simon S Mollevi Caroline C Adenis Antoine A El Messaoudi Safia S Blache Philippe P Thierry Alain R AR
Scientific reports 20190326 1
To our knowledge, this is the first comprehensive study on the influence of several pre-analytical and demographic parameters that could be a source of variability in the quantification of nuclear and mitochondrial circulating DNA (NcirDNA and McirDNA). We report data from a total of 222 subjects, 104 healthy individuals and 118 metastatic colorectal cancer (mCRC) patients. Approximately 50,000 and 3,000-fold more mitochondrial than nuclear genome copies were found in the plasma of healthy indiv ...[more]