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Clinical predictors of radiation-induced lymphopenia in patients receiving chemoradiation for glioblastoma: clinical usefulness of intensity-modulated radiotherapy in the immuno-oncology era.

ABSTRACT: BACKGROUND:Immunotherapy is currently being examined as a treatment modality for glioblastoma. Maintaining an optimal total lymphocyte count (TLC) after radiotherapy (RT) and using temozolomide may be beneficial in optimizing immunotherapy. However, conventional temozolomide-based chemoradiation is known to induce immunosuppressive effects, including lymphopenia. Therefore, this study aimed to identify potential clinical predictors of acute severe lymphopenia (ASL) in patients receiving chemoradiation for glioblastoma. METHODS:We identified patients with glioblastoma treated with RT plus temozolomide from 2006 to 2017. ASL was defined as a TLC of

SUBMITTER: Byun HK

PROVIDER: S-EPMC6436232 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Clinical predictors of radiation-induced lymphopenia in patients receiving chemoradiation for glioblastoma: clinical usefulness of intensity-modulated radiotherapy in the immuno-oncology era.

Byun Hwa Kyung HK Kim Nalee N Yoon Hong In HI Kang Seok-Gu SG Kim Se Hoon SH Cho Jaeho J Baek Jong Geol JG Chang Jong Hee JH Suh Chang-Ok CO

Radiation oncology (London, England) 20190327 1

<h4>Background</h4>Immunotherapy is currently being examined as a treatment modality for glioblastoma. Maintaining an optimal total lymphocyte count (TLC) after radiotherapy (RT) and using temozolomide may be beneficial in optimizing immunotherapy. However, conventional temozolomide-based chemoradiation is known to induce immunosuppressive effects, including lymphopenia. Therefore, this study aimed to identify potential clinical predictors of acute severe lymphopenia (ASL) in patients receiving ...[more]

PMID: 30917849

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