Clinical predictors of radiation-induced lymphopenia in patients receiving chemoradiation for glioblastoma: clinical usefulness of intensity-modulated radiotherapy in the immuno-oncology era.
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ABSTRACT:
SUBMITTER: Byun HK
PROVIDER: S-EPMC6436232 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Clinical predictors of radiation-induced lymphopenia in patients receiving chemoradiation for glioblastoma: clinical usefulness of intensity-modulated radiotherapy in the immuno-oncology era.
Byun Hwa Kyung HK Kim Nalee N Yoon Hong In HI Kang Seok-Gu SG Kim Se Hoon SH Cho Jaeho J Baek Jong Geol JG Chang Jong Hee JH Suh Chang-Ok CO
Radiation oncology (London, England) 20190327 1
<h4>Background</h4>Immunotherapy is currently being examined as a treatment modality for glioblastoma. Maintaining an optimal total lymphocyte count (TLC) after radiotherapy (RT) and using temozolomide may be beneficial in optimizing immunotherapy. However, conventional temozolomide-based chemoradiation is known to induce immunosuppressive effects, including lymphopenia. Therefore, this study aimed to identify potential clinical predictors of acute severe lymphopenia (ASL) in patients receiving ...[more]
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