Ontology highlight
ABSTRACT:
SUBMITTER: Choi SH
PROVIDER: S-EPMC6436530 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Choi Seung Hoan SH Weng Lu-Chen LC Roselli Carolina C Lin Honghuang H Haggerty Christopher M CM Shoemaker M Benjamin MB Barnard John J Arking Dan E DE Chasman Daniel I DI Albert Christine M CM Chaffin Mark M Tucker Nathan R NR Smith Jonathan D JD Gupta Namrata N Gabriel Stacey S Margolin Lauren L Shea Marisa A MA Shaffer Christian M CM Yoneda Zachary T ZT Boerwinkle Eric E Smith Nicholas L NL Silverman Edwin K EK Redline Susan S Vasan Ramachandran S RS Burchard Esteban G EG Gogarten Stephanie M SM Laurie Cecelia C Blackwell Thomas W TW Abecasis Gonçalo G Carey David J DJ Fornwalt Brandon K BK Smelser Diane T DT Baras Aris A Dewey Frederick E FE Jaquish Cashell E CE Papanicolaou George J GJ Sotoodehnia Nona N Van Wagoner David R DR Psaty Bruce M BM Kathiresan Sekar S Darbar Dawood D Alonso Alvaro A Heckbert Susan R SR Chung Mina K MK Roden Dan M DM Benjamin Emelia J EJ Murray Michael F MF Lunetta Kathryn L KL Lubitz Steven A SA Ellinor Patrick T PT
JAMA 20181201 22
<h4>Importance</h4>Atrial fibrillation (AF) is the most common arrhythmia affecting 1% of the population. Young individuals with AF have a strong genetic association with the disease, but the mechanisms remain incompletely understood.<h4>Objective</h4>To perform large-scale whole-genome sequencing to identify genetic variants related to AF.<h4>Design, setting, and participants</h4>The National Heart, Lung, and Blood Institute's Trans-Omics for Precision Medicine Program includes longitudinal and ...[more]