Ontology highlight
ABSTRACT:
SUBMITTER: Fajardo-Lubian A
PROVIDER: S-EPMC6436753 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Fajardo-Lubián Alicia A Ben Zakour Nouri L NL Agyekum Alex A Qi Qin Q Iredell Jonathan R JR
PLoS pathogens 20190315 3
As human population density and antibiotic exposure increase, specialised bacterial subtypes have begun to emerge. Arising among species that are common commensals and infrequent pathogens, antibiotic-resistant 'high-risk clones' have evolved to better survive in the modern human. Here, we show that the major matrix porin (OmpK35) of Klebsiella pneumoniae is not required in the mammalian host for colonisation, pathogenesis, nor for antibiotic resistance, and that it is commonly absent in pathoge ...[more]