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Daytime midpoint as a digital biomarker for chronotype in bipolar disorder.


ABSTRACT: BACKGROUND:Bipolar disorder (BD) is associated with later sleep and daily activity (evening rather than morning chronotype). Objective chronotype identification (e.g., based on actigraphs/smartphones) has potential utility, but to date, chronotype has mostly been assessed by questionnaires. Given the ubiquity of accelerometer-based devices (e.g. actigraphs/smartphones) worn/used during daytime and tendency to recharge rather than wear at night, we assessed chronotype using daytime (rather than sleep) interval midpoints. METHODS:Sixty-one participants with BD type I (BD-I) or II (BD-II) and 61 healthy controls completed 25-50 days of continuous actigraphy. The Composite Scale of Morningness (CSM) was completed by a subset of this group. Daytime activity midpoint was calculated for each daytime interval, excluding naps. Evening chronotype was defined as having a daytime interval midpoint at or after 16:15:00 (4:15:00 PM). RESULTS:BD versus controls had delayed daytime midpoint (mean?±?standard deviation) (16:49:07?±?01:26:19 versus 16:12:51?±?01:02:14, p?

SUBMITTER: Kaufmann CN 

PROVIDER: S-EPMC6436809 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Daytime midpoint as a digital biomarker for chronotype in bipolar disorder.

Kaufmann Christopher N CN   Gershon Anda A   Depp Colin A CA   Miller Shefali S   Zeitzer Jamie M JM   Ketter Terence A TA  

Journal of affective disorders 20180810


<h4>Background</h4>Bipolar disorder (BD) is associated with later sleep and daily activity (evening rather than morning chronotype). Objective chronotype identification (e.g., based on actigraphs/smartphones) has potential utility, but to date, chronotype has mostly been assessed by questionnaires. Given the ubiquity of accelerometer-based devices (e.g. actigraphs/smartphones) worn/used during daytime and tendency to recharge rather than wear at night, we assessed chronotype using daytime (rathe  ...[more]

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