DNA methylation variability in Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Huo Z
PROVIDER: S-EPMC6436841 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
DNA methylation variability in Alzheimer's disease.
Huo Zhiguang Z Zhu Yun Y Yu Lei L Yang Jingyun J De Jager Philip P Bennett David A DA Zhao Jinying J
Neurobiology of aging 20181221
DNA methylation plays a critical role in brain aging and Alzheimer's disease (AD). While prior studies have largely focused on testing mean DNA methylation, DNA methylation instability (quantified by DNA methylation variability) may also affect disease susceptibility. Using DNA methylation data collected by the Religious Orders Study and the Rush Memory and Aging Project, we identified 249 and 115 variably methylated probes (VMPs) associated with amyloid-β and neurofibrillary tangles, respective ...[more]
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