Ontology highlight
ABSTRACT:
SUBMITTER: Tian Y
PROVIDER: S-EPMC6436856 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Tian Yuan Y Babor Mariana M Lane Jerome J Seumois Grégory G Liang Shu S Goonawardhana N D Suraj NDS De Silva Aruna D AD Phillips Elizabeth J EJ Mallal Simon A SA da Silva Antunes Ricardo R Grifoni Alba A Vijayanand Pandurangan P Weiskopf Daniela D Peters Bjoern B Sette Alessandro A
The Journal of clinical investigation 20190318 4
Accumulating evidence demonstrates that CD8+ T cells contribute to protection from severe dengue virus (DENV) disease and vaccine efficacy. Nevertheless, molecular programs associated with DENV-specific CD8+ T cell subsets have not been defined. Here, we studied the transcriptomic profiles of human DENV-specific CD8+ T cells isolated after stimulation with DENV epitopes from donors who had been infected with DENV multiple times and would therefore be expected to have significant levels of adapti ...[more]