Ontology highlight
ABSTRACT:
SUBMITTER: Gruosso T
PROVIDER: S-EPMC6436884 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Gruosso Tina T Gigoux Mathieu M Manem Venkata Satya Kumar VSK Bertos Nicholas N Zuo Dongmei D Perlitch Irina I Saleh Sadiq Mehdi Ismail SMI Zhao Hong H Souleimanova Margarita M Johnson Radia Marie RM Monette Anne A Ramos Valentina Muñoz VM Hallett Michael Trevor MT Stagg John J Lapointe Réjean R Omeroglu Atilla A Meterissian Sarkis S Buisseret Laurence L Van den Eynden Gert G Salgado Roberto R Guiot Marie-Christine MC Haibe-Kains Benjamin B Park Morag M
The Journal of clinical investigation 20190318 4
Understanding the tumor immune microenvironment (TIME) promises to be key for optimal cancer therapy, especially in triple-negative breast cancer (TNBC). Integrating spatial resolution of immune cells with laser capture microdissection gene expression profiles, we defined distinct TIME stratification in TNBC, with implications for current therapies including immune checkpoint blockade. TNBCs with an immunoreactive microenvironment exhibited tumoral infiltration of granzyme B+CD8+ T cells (GzmB+C ...[more]