Ontology highlight
ABSTRACT:
SUBMITTER: Booty LM
PROVIDER: S-EPMC6436940 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Booty Lee M LM Gawel Justyna M JM Cvetko Filip F Caldwell Stuart T ST Hall Andrew R AR Mulvey John F JF James Andrew M AM Hinchy Elizabeth C EC Prime Tracy A TA Arndt Sabine S Beninca Cristiane C Bright Thomas P TP Clatworthy Menna R MR Ferdinand John R JR Prag Hiran A HA Logan Angela A Prudent Julien J Krieg Thomas T Hartley Richard C RC Murphy Michael P MP
Cell chemical biology 20190131 3
Mitochondrial glutathione (GSH) and thioredoxin (Trx) systems function independently of the rest of the cell. While maintenance of mitochondrial thiol redox state is thought vital for cell survival, this was not testable due to the difficulty of manipulating the organelle's thiol systems independently of those in other cell compartments. To overcome this constraint we modified the glutathione S-transferase substrate and Trx reductase (TrxR) inhibitor, 1-chloro-2,4-dinitrobenzene (CDNB) by conjug ...[more]