Ontology highlight
ABSTRACT:
SUBMITTER: Katrancha SM
PROVIDER: S-EPMC6436967 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Katrancha Sara Marie SM Shaw Juliana E JE Zhao Amy Y AY Myers Samuel A SA Cocco Alexandra R AR Jeng Amanda T AT Zhu Minsheng M Pittenger Christopher C Greer Charles A CA Carr Steven A SA Xiao Xiao X Koleske Anthony J AJ
Cell reports 20190301 10
Heterozygous coding mutations in TRIO are associated with neurodevelopmental disorders, including autism, schizophrenia, bipolar disorder, and epilepsy, and impair TRIO's biochemical activities. To model mutant alleles, we ablated one or both Trio alleles from excitatory neurons in the cortex and hippocampus of mice. Trio haploinsufficiency increases anxiety and impairs social preference and motor coordination. Trio loss reduces forebrain size and dendritic arborization but increases dendritic s ...[more]