Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC6437023 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Zhao Ying Y Yu Jinlong J Zhao Juan J Chen Xiaowu X Xiong Nian N Wang Tao T Qing Hong H Lin Zhicheng Z
Molecular neurobiology 20180927 6
A promoter can be regulated by various cis-acting elements so that delineation of the regulatory modes among them may help understand developmental, environmental and genetic mechanisms in gene activity. Here we report that the human dopamine transporter gene SLC6A3 carries a 5' distal 5-kb super enhancer (5KSE) which upregulated the promoter by 5-fold. Interestingly, 5KSE is able to prevent 3' downstream variable number tandem repeats (3'VNTRs) from silencing the promoter. This new enhancer con ...[more]