Ontology highlight
ABSTRACT:
SUBMITTER: Madar AD
PROVIDER: S-EPMC6437159 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Madar Antoine D AD Ewell Laura A LA Jones Mathew V MV
Scientific reports 20190327 1
Pattern separation is a process that minimizes overlap between patterns of neuronal activity representing similar experiences. Theoretical work suggests that the dentate gyrus (DG) performs this role for memory processing but a direct demonstration is lacking. One limitation is the difficulty to measure DG inputs and outputs simultaneously. To rigorously assess pattern separation by DG circuitry, we used mouse brain slices to stimulate DG afferents and simultaneously record DG granule cells (GCs ...[more]