Ontology highlight
ABSTRACT:
SUBMITTER: Ren F
PROVIDER: S-EPMC6437178 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Ren Feifei F Logeman Brandon L BL Zhang Xiaohui X Liu Yongjian Y Thiele Dennis J DJ Yuan Peng P
Nature communications 20190327 1
Copper (Cu) is an essential trace element for growth and development and abnormal Cu levels are associated with anemia, metabolic disease and cancer. Evolutionarily conserved from fungi to humans, the high-affinity Cu<sup>+</sup> transporter Ctr1 is crucial for both dietary Cu uptake and peripheral distribution, yet the mechanisms for selective permeation of potentially toxic Cu<sup>+</sup> ions across cell membranes are unknown. Here we present X-ray crystal structures of Ctr1 from Salmo salar ...[more]