Ontology highlight
ABSTRACT:
SUBMITTER: Basu T
PROVIDER: S-EPMC6437206 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Basu Trina T O'Riordan Kenneth J KJ Schoenike Barry A BA Khan Nadia N NN Wallace Eli P EP Rodriguez Genesis G Maganti Rama K RK Roopra Avtar A
Scientific reports 20190327 1
Abnormal synaptic plasticity has been implicated in several neurological disorders including epilepsy, dementia and Autism Spectrum Disorder (ASD). Tuberous Sclerosis Complex (TSC) is an autosomal dominant genetic disorder that manifests with seizures, autism, and cognitive deficits. The abnormal intracellular signaling underlying TSC has been the focus of many studies. However, nothing is known about the role of histone modifications in contributing to the neurological manifestations in TSC. Dy ...[more]