Ontology highlight
ABSTRACT:
SUBMITTER: Rybak JM
PROVIDER: S-EPMC6437491 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20190327 4
<i>Candida auris</i> has rapidly emerged as a health care-associated and multidrug-resistant pathogen of global concern. In this work, we examined the relative expression of the four <i>C. auris</i> genes with the highest degree of homology to <i>Candida albicans</i><i>CDR1</i> and <i>MDR1</i> among three triazole-resistant clinical isolates as compared to the triazole-susceptible genome reference clinical isolate. We subsequently utilized a novel Cas9-mediated system for genetic manipulations t ...[more]