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In Vitro and Intracellular Activity of Imipenem Combined with Tedizolid, Rifabutin, and Avibactam against Mycobacterium abscessus.

ABSTRACT: Mycobacterium abscessus infections are difficult to treat because of their resistance to many antibiotics. In vitro, tedizolid combined with imipenem displayed a moderate synergistic effect (fractional inhibitory concentration index, 0.41) but no bactericidal activity. Intracellularly, tedizolid 2??g/ml (half of the MIC), corresponding to the peak serum concentration, increased the efficacy of imipenem at 8 and 32??g/ml. Addition of avibactam and rifabutin, alone or in combination, improved the activity of the imipenem-tedizolid combination.

SUBMITTER: Le Run E 

PROVIDER: S-EPMC6437523 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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<i>In Vitro</i> and Intracellular Activity of Imipenem Combined with Tedizolid, Rifabutin, and Avibactam against <i>Mycobacterium abscessus</i>.

Le Run Eva E   Arthur Michel M   Mainardi Jean-Luc JL  

Antimicrobial agents and chemotherapy 20190327 4

<i>Mycobacterium abscessus</i> infections are difficult to treat because of their resistance to many antibiotics. <i>In vitro</i>, tedizolid combined with imipenem displayed a moderate synergistic effect (fractional inhibitory concentration index, 0.41) but no bactericidal activity. Intracellularly, tedizolid 2 μg/ml (half of the MIC), corresponding to the peak serum concentration, increased the efficacy of imipenem at 8 and 32 μg/ml. Addition of avibactam and rifabutin, alone or in combination,  ...[more]

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