Ontology highlight
ABSTRACT:
SUBMITTER: Le Run E
PROVIDER: S-EPMC6437523 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20190327 4
<i>Mycobacterium abscessus</i> infections are difficult to treat because of their resistance to many antibiotics. <i>In vitro</i>, tedizolid combined with imipenem displayed a moderate synergistic effect (fractional inhibitory concentration index, 0.41) but no bactericidal activity. Intracellularly, tedizolid 2 μg/ml (half of the MIC), corresponding to the peak serum concentration, increased the efficacy of imipenem at 8 and 32 μg/ml. Addition of avibactam and rifabutin, alone or in combination, ...[more]