Ontology highlight
ABSTRACT:
SUBMITTER: Gurevich VV
PROVIDER: S-EPMC6437759 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Gurevich Vsevolod V VV Chen Qiuyan Q Gurevich Eugenia V EV
Progress in molecular biology and translational science 20180906
Arrestins were discovered as proteins that bind active phosphorylated G protein-coupled receptors (GPCRs) and block their interactions with G proteins, i.e., for their role in homologous desensitization of GPCRs. Mammals express only four arrestin subtypes, two of which are largely restricted to the retina. Two nonvisual arrestins are ubiquitous and interact with hundreds of different GPCRs and dozens of other binding partners. Changes of just a few residues on the receptor-binding surface were ...[more]