Type 1 diabetes-associated cognitive impairment and diabetic peripheral neuropathy in Chinese adults: results from a prospective cross-sectional study.

ABSTRACT: BACKGROUND:To compare neurocognitive functioning of Type 1 diabetic mellitus (T1DM) and healthy adults, and explore risk factors of cognitive dysfunction of T1DM patients, especially the association between cognitive impairment and diabetic peripheral neuropathy (DPN). METHODS:Seventy T1DM (age: 32.17?±?9.57?yr., duration: 8.99?±?7.02?yr) patients and 48 healthy volunteers were included. All subjects received evaluation of MMSE and MoCA scales. Cognitive function of T1DM patients was evaluated in different cognitive domains. Risk factors affecting cognitive function were further explored. RESULTS:Three patients with educational level???6-year were excluded from final analysis. Scores of both MMSE (28.4?±?1.7 vs. 29.1?±?1.0, P?=?0.005) and MoCA scales (25.9?±?2.7 vs.27.1?±?2.4, P?=?0.017) in T1DM group were lower than that in control group. For MMSE scale, scores of orientation (9.60?±?0.79 vs.9.87?±?0.39, P?

SUBMITTER: Ding X 

PROVIDER: S-EPMC6437981 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature