Ontology highlight
ABSTRACT:
SUBMITTER: Skjesol A
PROVIDER: S-EPMC6438586 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
PLoS pathogens 20190318 3
Phagocytosis is a complex process that eliminates microbes and is performed by specialised cells such as macrophages. Toll-like receptor 4 (TLR4) is expressed on the surface of macrophages and recognizes Gram-negative bacteria. Moreover, TLR4 has been suggested to play a role in the phagocytosis of Gram-negative bacteria, but the mechanisms remain unclear. Here we have used primary human macrophages and engineered THP-1 monocytes to show that the TLR4 sorting adapter, TRAM, is instrumental for p ...[more]