Ontology highlight
ABSTRACT:
SUBMITTER: Rademacher N
PROVIDER: S-EPMC6438691 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Rademacher Nils N Kuropka Benno B Kunde Stella-Amrei SA Wahl Markus C MC Freund Christian C Shoichet Sarah A SA
eLife 20190313
PSD-95 MAGUK family scaffold proteins are multi-domain organisers of synaptic transmission that contain three PDZ domains followed by an SH3-GK domain tandem. This domain architecture allows coordinated assembly of protein complexes composed of neurotransmitter receptors, synaptic adhesion molecules and downstream signalling effectors. Here we show that binding of monomeric CRIPT-derived PDZ<sub>3</sub> ligands to the third PDZ domain of PSD-95 induces functional changes in the intramolecular SH ...[more]