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Late onset neonatal acute kidney injury: results from the AWAKEN Study.


ABSTRACT: BACKGROUND:Most studies of neonatal acute kidney injury (AKI) have focused on the first week following birth. Here, we determined the outcomes and risk factors for late AKI (>7d). METHODS:The international AWAKEN study examined AKI in neonates admitted to an intensive care unit. Late AKI was defined as occurring >7 days after birth according to the KDIGO criteria. Models were constructed to assess the association between late AKI and death or length of stay. Unadjusted and adjusted odds for late AKI were calculated for each perinatal factor. RESULTS:Late AKI occurred in 202/2152 (9%) of enrolled neonates. After adjustment, infants with late AKI had higher odds of death (aOR:2.1, p?=?0.02) and longer length of stay (parameter estimate: 21.9, p?

SUBMITTER: Charlton JR 

PROVIDER: S-EPMC6438709 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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<h4>Background</h4>Most studies of neonatal acute kidney injury (AKI) have focused on the first week following birth. Here, we determined the outcomes and risk factors for late AKI (>7d).<h4>Methods</h4>The international AWAKEN study examined AKI in neonates admitted to an intensive care unit. Late AKI was defined as occurring >7 days after birth according to the KDIGO criteria. Models were constructed to assess the association between late AKI and death or length of stay. Unadjusted and adjuste  ...[more]

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