Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome.
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ABSTRACT:
SUBMITTER: Semick SA
PROVIDER: S-EPMC6438764 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome.
Semick Stephen A SA Collado-Torres Leonardo L Markunas Christina A CA Shin Joo Heon JH Deep-Soboslay Amy A Tao Ran R Huestis Marilyn A MA Bierut Laura J LJ Maher Brion S BS Johnson Eric O EO Hyde Thomas M TM Weinberger Daniel R DR Hancock Dana B DB Kleinman Joel E JE Jaffe Andrew E AE
Molecular psychiatry 20180821 12
Cigarette smoking during pregnancy is a major public health concern. While there are well-described consequences in early child development, there is very little known about the effects of maternal smoking on human cortical biology during prenatal life. We therefore performed a genome-wide differential gene expression analysis using RNA sequencing (RNA-seq) on prenatal (N = 33; 16 smoking-exposed) as well as adult (N = 207; 57 active smokers) human postmortem prefrontal cortices. Smoking exposur ...[more]
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