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ABSTRACT: Background
Little is known about atopic dermatitis (AD) among children in Puerto Rico.Objective
To examine risk factors and identify approaches to better diagnose AD in Puerto Rican children.Methods
Case-control study of AD among 540 children aged 6-14 years in San Juan, Puerto Rico. AD was defined as: 1) physician-diagnosed AD, 2) RAST-AD: AD symptoms plus ≥1 positive IgE to allergens, and 3) STR-AD: AD-symptoms and skin test reactivity to ≥1 allergen. Logistic regression was used for the multivariable analysis. We also evaluated the diagnostic performance of various approaches by comparing their sensitivity, specificity, positive predicted value [PPV], negative predictive value [NPV], and area under curve [AUC]).Results
Of the 70 children with STR-AD, only 5 (7.1%) had PD-AD. In children without asthma, a positive IgE to Dermatophagoides (D.) pteronyssinus and signs of mold/mildew at home were significantly associated with 3.3 and 5 times increased odds of STR-AD, respectively. Among children with asthma, private/employer-based health insurance and a positive IgE to D. pteronyssinus were each significantly associated with approximately twofold increased odds of STR-AD. A combination of current eczema symptoms and a positive IgE to D. pteronyssinus yielded a sensitivity ≥ 70%, specificity and NPV ≥ 95%, PPV ≥ 88%, and an AUC ≥ 0.85 for STR-AD. Replacing a positive IgE to D. pteronyssinus with a positive IgE to ≥1 allergen slightly increased sensitivity without affecting other parameters.Conclusions
AD is markedly under-diagnosed by physicians in Puerto Rico. This could be improved by assessing eczema symptoms and measuring IgEs to common allergens.
SUBMITTER: Yang G
PROVIDER: S-EPMC6439410 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Yang Ge G Han Yueh-Ying YY Forno Erick E Acosta-Pérez Edna E Colón-Semidey Angel A Alvarez María M Canino Glorisa G Chen Wei W Celedón Juan C JC
The World Allergy Organization journal 20190126 1
<h4>Background</h4>Little is known about atopic dermatitis (AD) among children in Puerto Rico.<h4>Objective</h4>To examine risk factors and identify approaches to better diagnose AD in Puerto Rican children.<h4>Methods</h4>Case-control study of AD among 540 children aged 6-14 years in San Juan, Puerto Rico. AD was defined as: 1) physician-diagnosed AD, 2) RAST-AD: AD symptoms plus ≥1 positive IgE to allergens, and 3) STR-AD: AD-symptoms and skin test reactivity to ≥1 allergen. Logistic regressio ...[more]