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Amyloid involvement in subcortical regions predicts cognitive decline.


ABSTRACT: PURPOSE:We estimated whether amyloid involvement in subcortical regions may predict cognitive impairment, and established an amyloid staging scheme based on degree of subcortical amyloid involvement. METHODS:Data from 240 cognitively normal older individuals, 393 participants with mild cognitive impairment, and 126 participants with Alzheimer disease were acquired at Alzheimer's Disease Neuroimaging Initiative sites. To assess subcortical involvement, we analyzed amyloid deposition in amygdala, putamen, and caudate nucleus. We staged participants into a 3-stage model based on cortical and subcortical amyloid involvement: 382 with no cortical or subcortical involvement as stage 0, 165 with cortical but no subcortical involvement as stage 1, and 203 with both cortical and subcortical involvement as stage 2. RESULTS:Amyloid accumulation was first observed in cortical regions and spread down to the putamen, caudate nucleus, and amygdala. In longitudinal analysis, changes in MMSE, ADAS-cog 13, FDG PET SUVR, and hippocampal volumes were steepest in stage 2 followed by stage 1 then stage 0 (p value <0.001). Stage 2 showed steeper changes in MMSE score (? [SE]?=?-0.02 [0.004], p?

SUBMITTER: Cho SH 

PROVIDER: S-EPMC6439472 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Amyloid involvement in subcortical regions predicts cognitive decline.

Cho Soo Hyun SH   Shin Jeong-Hyeon JH   Jang Hyemin H   Park Seongbeom S   Kim Hee Jin HJ   Kim Si Eun SE   Kim Seung Joo SJ   Kim Yeshin Y   Lee Jin San JS   Na Duk L DL   Lockhart Samuel N SN   Rabinovici Gil D GD   Seong Joon-Kyung JK   Seo Sang Won SW  

European journal of nuclear medicine and molecular imaging 20180706 13


<h4>Purpose</h4>We estimated whether amyloid involvement in subcortical regions may predict cognitive impairment, and established an amyloid staging scheme based on degree of subcortical amyloid involvement.<h4>Methods</h4>Data from 240 cognitively normal older individuals, 393 participants with mild cognitive impairment, and 126 participants with Alzheimer disease were acquired at Alzheimer's Disease Neuroimaging Initiative sites. To assess subcortical involvement, we analyzed amyloid depositio  ...[more]

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