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Outcomes From Transcatheter Aortic Valve Replacement in Patients With Low-Flow, Low-Gradient Aortic Stenosis and Left Ventricular Ejection Fraction Less Than 30%: A Substudy From the TOPAS-TAVI Registry.


ABSTRACT: Importance:In low-flow, low-gradient aortic stenosis (LFLG AS), the severity of left ventricular dysfunction remains a key factor in the evaluation of aortic valve replacement. Objective:To evaluate the clinical outcomes and changes in left ventricular ejection fraction (LVEF) after transcatheter aortic valve replacement (TAVR) in patients with LFLG AS and severe left ventricular dysfunction. Design, Setting, and Participants:This multicenter registry is a substudy of the True or Pseudo-Severe Aortic Stenosis-TAVI registry that included patients with classic LFLG AS, defined as a mean transvalvular gradient less than 35 mm Hg, an effective orifice area less than 1.0 cm2, and an LVEF of 40% or less. Patients were divided in groups with very low (<30%) LVEF and low (30%-40%) LVEF. Dobutamine stress echocardiography (DSE) was performed before TAVR in a subset with very low LVEF, and presence of contractile reserve was defined as an increase of 20% or more in stroke volume. Clinical outcomes were assessed at 1 and 12 months and yearly thereafter, and echocardiography was performed at 1-year follow-up. Retrospective data were collected from 2007 to 2013 and prospective data from January 2013 to March 2018. Data were analyzed from March to October 2018. Exposures:Transcatheter aortic valve replacement in patients with LFLG AS. Main Outcomes and Measures:Changes in LVEF over time; periprocedural and late mortality. Results:A total of 293 patients were included, including 128 (43.7%) with very low LVEF and 165 with low LVEF (56.3%). Their mean (SD) age was 80 (7) years, and most (214 [73.0%]) were men. The mean (SD) LVEF in the very low LVEF group was 22% (5%), compared with 37% (7%) in the low LVEF group (P?

SUBMITTER: Maes F 

PROVIDER: S-EPMC6439680 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Outcomes From Transcatheter Aortic Valve Replacement in Patients With Low-Flow, Low-Gradient Aortic Stenosis and Left Ventricular Ejection Fraction Less Than 30%: A Substudy From the TOPAS-TAVI Registry.

Maes Frédéric F   Lerakis Stamatios S   Barbosa Ribeiro Henrique H   Gilard Martine M   Cavalcante João L JL   Makkar Raj R   Herrmann Howard C HC   Windecker Stephan S   Enriquez-Sarano Maurice M   Cheema Asim N AN   Nombela-Franco Luis L   Amat-Santos Ignacio I   Muñoz-García Antonio J AJ   Garcia Del Blanco Bruno B   Zajarias Alan A   Lisko John C JC   Hayek Salim S   Babaliaros Vasilis V   Le Ven Florent F   Gleason Thomas G TG   Chakravarty Tarun T   Szeto Wilson W   Clavel Marie-Annick MA   de Agustin Alberto A   Serra Vicenç V   Schindler John T JT   Dahou Abdellaziz A   Salah-Annabi Mohammed M   Pelletier-Beaumont Emilie E   Côté Melanie M   Puri Rishi R   Pibarot Philippe P   Rodés-Cabau Josep J  

JAMA cardiology 20190101 1


<h4>Importance</h4>In low-flow, low-gradient aortic stenosis (LFLG AS), the severity of left ventricular dysfunction remains a key factor in the evaluation of aortic valve replacement.<h4>Objective</h4>To evaluate the clinical outcomes and changes in left ventricular ejection fraction (LVEF) after transcatheter aortic valve replacement (TAVR) in patients with LFLG AS and severe left ventricular dysfunction.<h4>Design, setting, and participants</h4>This multicenter registry is a substudy of the T  ...[more]

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