Association of Genetic vs Environmental Factors in Swedish Adoptees With Clinically Significant Tinnitus.

ABSTRACT:

Importance

No effective treatments are currently available for severe tinnitus, which affects 1% of the population and lowers the quality of life. The factors that contribute to the transition from mild to severe tinnitus are poorly known. Before performing genetic analyses and determining the mechanisms involved in the development of severe tinnitus, its heritability needs to be determined.

Objectives

To examine whether clinically significant tinnitus is associated with genetic factors and to evaluate the genetic risk in the transmission of tinnitus using adoptees.

Design, setting, and participants

Data from adoptees and their biological and adoptive parents from Swedish nationwide registers were collected from January 1, 1964, to December 31, 2015, and used to separ

SUBMITTER: Cederroth CR 

PROVIDER: S-EPMC6439751 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature