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Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury: A Systematic Review and Meta-analysis.


ABSTRACT: Importance:Covert vascular brain injury (VBI) is highly prevalent in community-dwelling older persons, but its clinical and therapeutic implications are debated. Objective:To better understand the clinical significance of VBI to optimize prevention strategies for the most common age-related neurological diseases, stroke and dementia. Data Source:We searched for articles in PubMed between 1966 and December 22, 2017, studying the association of 4 magnetic resonance imaging (MRI) markers of covert VBI (white matter hyperintensities [WMHs] of presumed vascular origin, MRI-defined covert brain infarcts [BIs], cerebral microbleeds [CMBs], and perivascular spaces [PVSs]) with incident stroke, dementia, or death. Study Selection:Data were taken from prospective, longitudinal cohort studies including 50 or more adults. Data Extraction and Synthesis:We performed inverse variance-weighted meta-analyses with random effects and z score-based meta-analyses for WMH burden. The significance threshold was P?

SUBMITTER: Debette S 

PROVIDER: S-EPMC6439887 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury: A Systematic Review and Meta-analysis.

Debette Stéphanie S   Schilling Sabrina S   Duperron Marie-Gabrielle MG   Larsson Susanna C SC   Markus Hugh S HS  

JAMA neurology 20190101 1


<h4>Importance</h4>Covert vascular brain injury (VBI) is highly prevalent in community-dwelling older persons, but its clinical and therapeutic implications are debated.<h4>Objective</h4>To better understand the clinical significance of VBI to optimize prevention strategies for the most common age-related neurological diseases, stroke and dementia.<h4>Data source</h4>We searched for articles in PubMed between 1966 and December 22, 2017, studying the association of 4 magnetic resonance imaging (M  ...[more]

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