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Effect of CD14 polymorphisms on the risk of cardiovascular disease: evidence from a meta-analysis.

ABSTRACT: BACKGROUND:CD14 polymorphisms are associated with an increased risk of cardiovascular events. So far, many studies have been conducted, whereas the results were not always consistent. MATERIALS AND METHODS:Twenty-six articles involving thirty-seven datasets were recruited to evaluate the association between rs2569190 (9413 patients and 7337 controls), C-159T (4813 patients and 2852 controls) polymorphisms and cardiovascular diseases in a meta-analysis. The random or fixed effect models were used to evaluate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals. RESULTS:The strongest association was observed between rs2569190 and CVD in overall population (T vs. C, OR?=?1.169, 95% CI: 1.087-1.257, p?=?2.44?×?10-?5). Analysis after stratification by ethnicity indicated that rs2569190 was related to CVD in East Asian population (T vs. C, OR?=?1.370, 95% CI; 1.226-1.531, p?=?2.86?×?10-?8) and a potential relationship in European (T vs. C, OR?=?1.100, 95% CI: 1.019-1.189, p?=?0.015). In the stratification of endpoints, the associations were found in CHD subgroup (T vs. C, OR?=?1.357, 95% CI: 1.157-1.592, p?=?2.47?×?10-?7) and in AMI subgroup (T vs. C, OR?=?1.152, 95% CI: 1.036-1.281, p?=?0.009). However, we did not find any association between C-159T polymorphism with cardiovascular disease under any model. CONCLUSIONS:The SNP rs2569190 significantly contribute to susceptibility and development of cardiovascular disease, particularly in the East Asian population and in the subtype CHD group, in addition, a potential association was observed in the AMI group, T allele acts as a risk factor for cardiovascular disease.

SUBMITTER: Xu JJ

PROVIDER: S-EPMC6439994 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Effect of CD14 polymorphisms on the risk of cardiovascular disease: evidence from a meta-analysis.

Xu Jin-Jian JJ Liu Ke-Qi KQ Ying Zhi-Min ZM Zhu Xiao-Wei XW Xu Xue-Jin XJ Zhao Pian-Pian PP Bai Wei-Yang WY Qiu Mo-Chang MC Zhang Xing-Wei XW Zheng Hou-Feng HF

Lipids in health and disease 20190328 1

<h4>Background</h4>CD14 polymorphisms are associated with an increased risk of cardiovascular events. So far, many studies have been conducted, whereas the results were not always consistent.<h4>Materials and methods</h4>Twenty-six articles involving thirty-seven datasets were recruited to evaluate the association between rs2569190 (9413 patients and 7337 controls), C-159T (4813 patients and 2852 controls) polymorphisms and cardiovascular diseases in a meta-analysis. The random or fixed effect m ...[more]

PMID: 30922395

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Dataset Information

Effect of CD14 polymorphisms on the risk of cardiovascular disease: evidence from a meta-analysis.

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Effect of CD14 polymorphisms on the risk of cardiovascular disease: evidence from a meta-analysis.

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