Ontology highlight
ABSTRACT:
SUBMITTER: Duffy FJ
PROVIDER: S-EPMC6440524 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Duffy Fergal J FJ Weiner January J Hansen Scott S Tabb David L DL Suliman Sara S Thompson Ethan E Maertzdorf Jeroen J Shankar Smitha S Tromp Gerard G Parida Shreemanta S Dover Drew D Axthelm Michael K MK Sutherland Jayne S JS Dockrell Hazel M HM Ottenhoff Tom H M THM Scriba Thomas J TJ Picker Louis J LJ Walzl Gerhard G Kaufmann Stefan H E SHE Zak Daniel E DE
Frontiers in immunology 20190322
There remains a pressing need for biomarkers that can predict who will progress to active tuberculosis (TB) after exposure to Mycobacterium tuberculosis (MTB) bacterium. By analyzing cohorts of household contacts of TB index cases (HHCs) and a stringent non-human primate (NHP) challenge model, we evaluated whether integration of blood transcriptional profiling with serum metabolomic profiling can provide new understanding of disease processes and enable improved prediction of TB progression. Com ...[more]