Ontology highlight
ABSTRACT:
SUBMITTER: Takashita E
PROVIDER: S-EPMC6440584 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20190301 12
In January 2019, two influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic subunit (PA), which confers reduced susceptibility to baloxavir, were detected from epidemiologically unrelated hospitalised children in Japan. The viruses exhibited reduced susceptibility to baloxavir but were susceptible to neuraminidase inhibitors. Only one of the two children had been treated with baloxavir. An epidemiological analysis suggests possible transmission of the PA I38T mutant A(H ...[more]