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Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019.

ABSTRACT: In January 2019, two influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic subunit (PA), which confers reduced susceptibility to baloxavir, were detected from epidemiologically unrelated hospitalised children in Japan. The viruses exhibited reduced susceptibility to baloxavir but were susceptible to neuraminidase inhibitors. Only one of the two children had been treated with baloxavir. An epidemiological analysis suggests possible transmission of the PA I38T mutant A(H3N2) virus among humans.

SUBMITTER: Takashita E

PROVIDER: S-EPMC6440584 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019.

Takashita Emi E Kawakami Chiharu C Ogawa Rie R Morita Hiroko H Fujisaki Seiichiro S Shirakura Masayuki M Miura Hideka H Nakamura Kazuya K Kishida Noriko N Kuwahara Tomoko T Ota Akira A Togashi Hayato H Saito Ayako A Mitamura Keiko K Abe Takashi T Ichikawa Masataka M Yamazaki Masahiko M Watanabe Shinji S Odagiri Takato T

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20190301 12

In January 2019, two influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic subunit (PA), which confers reduced susceptibility to baloxavir, were detected from epidemiologically unrelated hospitalised children in Japan. The viruses exhibited reduced susceptibility to baloxavir but were susceptible to neuraminidase inhibitors. Only one of the two children had been treated with baloxavir. An epidemiological analysis suggests possible transmission of the PA I38T mutant A(H ...[more]

PMID: 30914078

Dataset Information

Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019.

Publications

Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019.

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