Ontology highlight
ABSTRACT:
SUBMITTER: Kolb R
PROVIDER: S-EPMC6440811 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Kolb Ryan R Kluz Paige P Tan Zhen Wei ZW Borcherding Nicholas N Bormann Nicholas N Vishwakarma Ajaykumar A Balcziak Louis L Zhu Pengcheng P Davies Brandon Sj BS Gourronc Francoise F Liu Ling-Zhi LZ Ge Xin X Jiang Bing-Hua BH Gibson-Corley Katherine K Klingelhutz Aloysius A Tan Nguan Soon NS Zhu Yuwen Y Sutterwala Fayyaz S FS Shen Xian X Zhang Weizhou W
Oncogene 20181205 13
Obesity is a risk factor for breast cancer and also predicts poor clinical outcomes regardless of menopausal status. Contributing to the poor clinical outcomes is the suboptimal efficacy of standard therapies due to dose limiting toxicities and obesity-related complications, highlighting the need to develop novel therapeutic approaches for treating obese patients. We recently found that obesity leads to an increase in tumor-infiltrating macrophages with activated NLRC4 inflammasome and increased ...[more]